HIV 1 Resistance
🪫 “HIV-1 Resistance”
One of the examples used by evolutionists as evidence of evolution is the ability of some individuals to resist the AIDS virus,
which led them to believe that humans acquired a constructive mechanism that enabled them to resist the virus —
and then… hope … this is evidence of evolution.
We will not elaborate on this nonsense.
🔍 To begin with:
- The AIDS virus infects T cells — which are immune cells found in white blood cells —
through a receptor on T cells called the chemokine receptor (CCR5) .
What happened then for the T cells to resist this virus?
🪫 They destroy the CCR5 receptor , from which the virus hunts T cells,
thus preventing the virus from hunting down the T cells.
A mutation has been proven to have occurred in the gene responsible for coding the CCR5 receptor ,
meaning an inactive allele of the CCR5 gene has been detected.
🧬 To clarify further:
- The active allele : Is the normal gene that produces the functional CCR5 receptor ,
which the virus uses to enter cells.
- The inactive allele (CCR5-2) : A mutant gene that produces a nonfunctional or absent CCR5 protein ,
preventing the virus from using it to enter cells.
📌 CCR5-2 was the only mutant allele found.
It was common in Caucasians, less common in other North American racial groups,
and not detected in West Africans or Tamil Indians.
Homozgyous CCR5-2 frequencies differed reciprocally in:
Highly exposed-seronegative (4.5%, n = 111)
HIV-1-seropositive (0%, n = 614)
compared to Caucasian random blood donors (0.8%, n = 387)
This difference was highly significant (p < 0.0001 ).
By contrast, heterozygous CCR5-2 frequencies did not differ significantly in the same three groups (21.6%, 22.6%, and 21.7%, respectively).
A 55% increase in the frequency of heterozygous CCR5-2 was observed in both of two cohorts of Caucasian homosexual males , long-term nonprogressors —
compared with other HIV-1+ Caucasian homosexuals.
Moreover, Kaplan-Meier estimates indicated that CCR5-2 heterozygous seroconverters had a 52.6% lower risk of developing AIDS than homozygous wild-type seroconverters.
📌 Conclusions:
The data suggest that homozygous CCR5-2 is an HIV-1 resistance factor in Caucasians with complete penetrance,
and that heterozygous CCR5-2 slows the rate of disease progression in infected Caucasian homosexuals.
Since the majority (approximately 96% ) of highly exposed-seronegative individuals tested are not homozygous for CCR5-2 ,
other resistance factors must exist.
Since CCR5-2 homozygotes have no obvious clinical problems,
CCR5 may be a good target for the development of novel antiretroviral therapy.
📎 https://pubmed.ncbi.nlm.nih.gov/9132277/
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https://pubmed.ncbi.nlm.nih.gov/9132277/
Inherited resistance to HIV-1 conferred by an inactivating mutation…
The data suggest that homozygous CCR5-2 is an HIV-1 resistance factor in Caucasians with complete penetrance, and that heterozygous CCR5-2 slows the rate of disease progression in infected Caucasian homosexuals. Since the majority (approximately 96%) of highly exposed-seronegative individuals tested …
